Overview

A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Kidney Stone Surgery (Percutaneous Nephrolithotomy [PCNL])

Status:
Completed

Trial end date:
2019-06-01

Target enrollment:

Participant gender:

Summary

When patients are going to have surgery to remove large kidney stones (percutaneous nephrolithotomy [PCNL]), it is not clear whether the patients benefit from a course of prophylactic preoperative oral antibiotics; currently both the use of prophylactic preoperative oral antibiotics and no prophylactic oral antibiotics are considered to be within standard-of-care. This study will randomize patients to preoperative prophylactic antibiotics or no antibiotics to determine if the use of preoperative prophylactic antibiotics decreases the postoperative risk of localized urinary tract infection (UTI) and/or systemic infection that started in the urinary tract (sepsis or urosepsis).

Phase:

Phase 4

Details

Lead Sponsor:

University of California, San Diego

Collaborators:

Dartmouth-Hitchcock Medical Center
Duke University
Mayo Clinic
New York University
Ohio State University
The Cleveland Clinic
University of British Columbia
Vanderbilt University

Treatments:

Ampicillin
Anti-Bacterial Agents
Antibiotics, Antitubercular
Ceftriaxone
Gentamicins
Nitrofurantoin
Vancomycin